Bat coronavirus BANAL20-236 Spike Trimer Protein (R677A, K978P,

The spike protein of bat coronavirus BANAL-20-236, a SARS-CoV-2–related sarbecovirus identified in Laos, mediates viral entry by promoting receptor attachment and membrane fusion. BANAL-20-236 shares high genomic similarity with SARS-CoV-2 and contains spike features relevant to cross-species transmission. Specific substitutions, such as P804L in the S2 subunit, have been linked to adaptation to a broad range of Rhinolophus bat ACE2 receptors, making it important for studies on coronavirus evolution and zoonotic spillover risk.