SARS-CoV-2 Spike RBD Protein, His Tag (LF.7) (MALS verified)

The SARS‑CoV‑2 lineage LF.7 is a subvariant within the JN.1 family, identified through genomic surveillance in 2024–2025. It carries multiple Spike protein mutations, some within the receptor‑binding domain, potentially affecting antibody recognition and viral fitness. LF.7 and its sublineages (e.g., LF.7.2.1) have been detected across several regions, showing moderate growth advantage over earlier strains. Preliminary studies suggest certain mutations may enhance immune evasion, though impacts on ACE2 binding vary. Continuous monitoring is recommended to assess its epidemiological significance, vaccine effectiveness, and role in ongoing SARS‑CoV‑2 evolution.