Human TIGIT (Luc) Jurkat Reporter Cell

T cell immunoglobulin and ITIM domain (TIGIT) is an immune checkpoint that has been considered as a target in cancer immunotherapy and belongs to the family of poliovirus receptors (PVRs) that competes against CD226 (DNAM-1), which is the co-stimulatory receptor of T cells and NK cells, by binding to CD112 and CD155 (PVR) that are expressed on antigen-presenting cells (APCs) and various non-hematopoietic cell types, such as tumor cells. The TIGIT/PVR axis imparts a co-inhibitory effect on both T and NK cells that lead to their exhaustion, in turn triggering a negative signal that suppresses their activities, resulting in tumor-immune evasion.