Human IL-11 R alpha (Luc) HEK293 Reporter Cell

IL-11 and IL-6 are signal transducer and activator of transcription 3 (STAT3) activators and frequently found upregulated in colorectal cancer (CRC). STAT3 activation in tumor epithelial cells is critically involved in the pathogenesis of CRC. Cancer-associated fibroblasts (CAFs) can modulate the tumor microenvironment in CRC. The latest research indicated that phosphorylation of STAT3 (pSTAT3) expression in CAFs is inversely correlated with the survival in CRC patients. IL-6 and IL-11 induce partly overlapping gene expression patterns in fibroblast subsets in CRC. In a summary, STAT3 activation in CAFs plays a key role in the cross-talk to the tumor epithelium.