Human VEGF R2 (Luc) HEK293 Reporter Cell

Vascular endothelial growth factor (VEGF) is a potent angiogenic inducer that stimulates the expression of tissue factor (TF), the major cellular initiator of blood coagulation. VEGF could inhibit apoptosis and increase cellular proliferation. As the most abundant splice variant of VEGF-A, VEGF165 binds to the receptor tyrosine kinases, VEGFR1 and VEGFR2, leads to activation of the PI3K/AKT, p38 MAPK, FAK, and paxillin. Due to the angiogenesis ability of VEGF in cancer, interfering VEGF/VEGFR2 interaction has become an attractive method in cancer therapy.

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